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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. 8, 2006, pp. 845-849
Bioline Code: oc06139
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 101, No. 8, 2006, pp. 845-849

 en Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil
Luzidalva Barbosa de Medeiros; Heloísa Ramos Lacerda; Ana Maria Salustiano Cavalcanti & Maria de Fátima Pessoa Militão de Albuquerque

Abstract

To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeqTM Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.

Keywords
human imunodeficiency virus type 1 - primary resistance to drugs - genotyping - subtypes - Brazil

 
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