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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. 8, 2006, pp. 895-898
Bioline Code: oc06147
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 101, No. 8, 2006, pp. 895-898

 en Capillaria hepatica check for this species in other resources in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
Ana Thereza Gomes; Liliane Monteiro Cunha; Carla Guimarães Bastos; Bruno Frederico Medrado; Bárbara CA Assis & Zilton A Andrade

Abstract

Capillaria hepatica check for this species in other resources causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.

Keywords
Capillaria hepatica - septal fibrosis - rats - corticosteroids - antigenic stimulation

 
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