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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. s1, 2006, pp. 157-160
Bioline Code: oc06183
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 101, No. s1, 2006, pp. 157-160

 en Characterization of the gene expression related to the process of DNA damage tolerance in Schistosoma mansoni check for this species in other resources
SH Silva; OS Pereira-Júnior; CS Silva; OM Brigatto; E Macedo & V Rodrigues

Abstract

In the course of its complex life cycle, the parasite Schistosoma mansoni check for this species in other resources need to adapt to distinct environments, and consequently is exposed to various DNA damaging agents. The Schistosoma genome sequencing initiative has uncovered sequences from genes and transcripts related to the process of DNA damage tolerance as the enzymes UBC13, MMS2, and RAD6. In the present work, we evaluate the importance of this process in different stages of the life cycle of this parasite. The importance is evidenced by expression and phylogenetic profiles, which show the conservation of this pathway from protozoa to mammalians on evolution.

Keywords
Schistosoma mansoni - ubiquitin conjugating enzymes - DNA damage tolerance

 
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