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Preliminary results on interleukin-4 and interleukin-10 cytokine production in malnourished, inducible nitric oxide synthase-deficient mice with schistosomiasis mansoni infection Renata P Ramos; Vlaudia MA Costa; Camila F Melo; Valdênia MO Souza; Elizabeth Malagueño; Eridan M Coutinho; Frederico G C Abath & Silvia ML Montenegro Abstract Schistosoma mansoni infected C57Bl/6 inducible nitric oxide synthase (iNOS)-deficient and non-deficient malnourished mice, both fed a balanced controlled diet were studied. Interleukins, IL-4 and IL-10 responses to soluble egg antigens (SEA) 90 days after infection, were determined. Our results suggest that in iNOS deficient, malnourished mice, 90 days after of infection, nitric oxide has a downregulating effect on IL-4 and IL-10 production. We are currently investigating the biological significance of these findings. Keywords Schistosoma mansoni - cytokines - malnutrition - mice

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