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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 102, No. 1, 2007, pp. 73-77
Bioline Code: oc07012
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 102, No. 1, 2007, pp. 73-77

 en Activity of Brazilian and Bulgarian propolis against different species of Leishmania check for this species in other resources
de Carvalho Machado, Gérzia Maria; Leon, Leonor Laura & De Castro, Solange Lisboa

Abstract

Extracts of propolis samples collected in Brazil and Bulgaria were assayed against four Leishmania species _ Leishmania amazonensis, L. braziliensis, L. chagasi from the New World, and L. majori from the Old World _ associated to different clinical forms of Leishmaniasis. The composition of the extracts has been previously characterized by high temperature high resolution gas chromatography coupled to mass spectrometry. Considering the chemical differences among the extracts and the behavior of the parasites, it was observed significant differences in the leishmanicidal activities with IC50/1 day values in the range of 2.8 to 229.3 µg/ml. An overall analysis showed that for all the species evaluated, Bulgarian extracts were more active than the ethanol Brazilian extract. As the assayed propolis extracts have their chemical composition determined it merits further investigation the effect of individual components or their combinations on each Leishmania species.

Keywords
Leishmania - Leishmaniasis - propolis - chemical composition - natural products

 
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