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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 102, No. 1, 2007, pp. 91-96
Bioline Code: oc07016
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 102, No. 1, 2007, pp. 91-96

 en Analgesic and anti-inflammatory activity of the aqueous extract of Rheedia longifolia Planch & Triana
da Silva Frutuoso, Valber; Monteiro, Márcia Magalhães; Amendoeira, Fábio Coelho; Almeida, Andressa Luiza Figueiredo; do Nascimento, Diogo Dibo; Bérenger, Ana Luiza Rangel; Kaplan, Maria Auxiliadora Coelho; Figueiredo, Maria Raquel; Bozza, Patrícia T & Castro-Faria-Neto, Hugo C

Abstract

Rheedia longifolia Planch et Triana belongs to the Clusiaceae family. This plant is widely distributed in Brazil, but its chemical and pharmacological properties have not yet been studied. We report here that leaves aqueous extract of R. longifolia (LAE) shows analgesic and anti-inflammatory effects. Oral or intraperitoneal administration of this extract dose-dependently inhibited the abdominal constrictions induced by acetic acid in mice. The analgesic effect and the duration of action were similar to those observed with sodium diclofenac, a classical non-steroidal analgesic. In addition to the effect seen in the abdominal constriction model, LAE was also able to inhibit the hyperalgesia induced by lipopolysaccharide from gram-negative bacteria (LPS) in rats. We also found that R. longifolia LAE inhibited an inflammatory reaction induced by LPS in the pleural cavity of mice. Acute toxicity was evaluated in mice treated with the extract for seven days with 50 mg/kg/day. Neither death, nor alterations in weight, blood leukocyte counts or hematocrit were noted. Our results suggest that aqueous extract from R. longifolia leaves has analgesic and anti-inflammatory activity with minimal toxicity and are therefore endowed with a potential for pharmacological control of pain and inflammation.

Keywords
Rheedia longifolia - analgesic - anti-inflammatory - opioid receptors - natural products

 
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