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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 102, No. 2, 2007, pp. 141-147
Bioline Code: oc07025
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 102, No. 2, 2007, pp. 141-147

 en Trypanosoma cruzi check for this species in other resources high infectivity in vitro is related to cardiac lesions during long-term infection in Beagle dogs
Guedes, Paulo MM; Veloso, Vanja M; Caliari, Marcelo V; Carneiro, Cláudia M; Souza, Sheler M; de Lana, Marta; Chiari, Egler; Bahia, Maria T & Galvão, Lúcia MC

Abstract

Trypanosoma cruzi check for this species in other resources is a hemoflagelate parasite associated with heart dysfunctions causing serious problems in Central and South America. Beagle dogs develop the symptoms of Chagas disease in humans, and could be an important experimental model for better understanding the immunopathogenic mechanisms involved in the chagasic infection. In the present study we investigated the relation among biological factors inherent to the parasite (trypomastigote polymorphism and in vitro infectivity) and immunoglobulin production, inflammation, and fibrosis in the heart of Beagle dogs infected with either T. cruzi Y or Berenice-78 strains. In vitro infectivity of Vero cells as well as the extension of cardiac lesions in infected Beagle was higher for Y strain when compared to Berenice-78 strain. These data suggested that in vitro infectivity assays may correlate with pathogenicity in vivo. In fact, animals infected with Y strain, which shows prevalence of slender forms and high infectivity in vitro, presented cardiomegaly, inflammation, and fibrosis in heart area. Concerning the immunoglobulin production, no statistically significant difference was observed for IgA, IgM or IgG levels among T. cruzi infected animals. However, IgA together IgM levels have shown to be a good marker for the acute phase of Chagas disease.

Keywords
Trypanosoma cruzi - Beagle dogs - infectivity - cardiac lesions - Chagas disease - antibodies

 
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