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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 102, No. 2, 2007, pp. 203-208
Bioline Code: oc07035
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 102, No. 2, 2007, pp. 203-208

 en Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys
Freire, MS; Marchevsky, RS; Almeida, LFC; Yamamura, AMY; Caride, EC; Brindeiro, PA; Motta, MCA; Nogueira, RMR; Kubelka, CF; Bonaldo, MC & Galler, R

Abstract

Among the flaviviruses, dengue, with its four serotypes, has spread throughout the tropics. The most advanced vaccines developed so far include live attenuated viruses, which have been tested in humans but none has been licensed. Preclinical testing of dengue vaccine candidates is performed initially in mice and in nonhuman primates. In the latter the main criteria used to assay protection are neutralizing antibodies elicited by the vaccine candidate and the magnitude and duration of peripheral viremia upon challenge of previously immunized animals. Towards the identification of wild-type viruses that could be used in challenge experiments a total of 31 rhesus monkeys were inoculated subcutaneously of wild dengue types 1, 2, and 3 viruses. The viremia caused by the different viruses was variable but it was possible to identify dengue viruses useful as challenge strains.

Keywords
flaviviruses - dengue virus - infectivity - rhesus monkeys

 
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