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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 102, No. 3, 2007, pp. 417-419
Bioline Code: oc07066
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 102, No. 3, 2007, pp. 417-419

 en Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo
Sowunmi, Akintunde; Gbotosho, Grace O; Happi, Christian T; Adedeji, Ahmed A; Bolaji, Olayinka M; Fehintola, Fatai A; Fateye, Babasola A & Oduola, Ayoade MJ

Abstract

Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 receptor antagonist that reverses chloroquine (CQ) resistance in vitro and enhances its efficacy in vivo, in five children who failed CQ and/or AQ treatment, and who were subsequently retreated and cured with a combination of AQ plus CP, despite the fact that parasites infecting the children harboured mutant pfcrtT76 and pfmdr1Y86 alleles associated with AQ resistance. This suggests a potential clinical appliation of the reversal phenomenon.

Keywords
amodiaquine - chlorpheniramine - resistance reversal - malaria - children

 
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