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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 102, No. 4, 2007, pp. 469-472
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Bioline Code: oc07074
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 102, No. 4, 2007, pp. 469-472
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In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus
Carriel-Gomes, Márcia Cristina; Kratz, Jadel Müller; Barracco, Margherita Anna; Bachére, Evelyne; Barardi, Célia Regina Monte & Simões, Cláudia Maria Oliveira
Abstract
Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated
from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of
nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus
respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they
were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications
on the peptide's structures may improve their selectivity and reduce their cytotoxicity.
Keywords
antimicrobial peptides - antiviral activity - herpesvirus - adenovirus - rotavirus
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