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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 3, 2008, pp. 221-235
Bioline Code: oc08041
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 3, 2008, pp. 221-235

 en Polysaccharide-rich fraction of Agaricus brasiliensis check for this species in other resources enhances the candidacidal activity of murine macrophages
Martins, Priscila Raquel; Gameiro, Maria Carolina; Castoldi, Lindsey; Romagnoli, Graziela Gorete; Lopes, Fabiane Catanho; Pinto, Andréa Vanessa Ferreira da Silva; Loyola, Wagner & Kaneno, Ramon

Abstract

A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis check for this species in other resources was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after 48 h their peritoneal resident macrophages were assayed against Candida albicans check for this species in other resources yeast forms. The treatment increased fungicidal activity and it was associated with higher levels of H2O2, whereas NO production was not affected. We also found that the treatment enhances mannose receptor expression by peritoneal macrophages, which are involved in the attachment and phagocytosis of non-opsonized microorganisms. Treatment of animals with ATF was able to enhance the clearance of C. albicans during the first 6 h after the experimental i.p. infection. Our results suggest that this extract can increase host resistance against some infectious agents through the stimulation of microbicidal activity of macrophages.

Keywords
Candida albicans - microbicidal activity - mushroom

 
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