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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 3, 2008, pp. 221-235
Bioline Code: oc08047
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 3, 2008, pp. 221-235

 en Antimicrobial activity of Brazilian copaiba oils obtained from different species of the Copaifera check for this species in other resources genus
dos Santos, Adriana Oliveira; Ueda-Nakamura, Tânia; Filho, Benedito Prado Dias; Junior, Valdir F Veiga; Pinto, Angelo C & Nakamura, Celso Vataru

Abstract

The antimicrobial activity of copaiba oils was tested against Gram-positive and Gram-negative bacteria, yeast, and dermatophytes. Oils obtained from Copaifera martii check for this species in other resources , Copaifera officinalis check for this species in other resources , and Copaifera reticulata check for this species in other resources (collected in the state of Acre) were active against Gram-positive species ( Staphylococcus aureus check for this species in other resources , methicillin-resistant S. aureus, Staphylococcus epidermidis check for this species in other resources , Bacillus subtilis check for this species in other resources , and Enterococcus faecalis check for this species in other resources ) with minimum inhibitory concentrations ranging from 31.3-62.5 μg/ml. The oils showed bactericidal activity, decreasing the viability of these Gram-positive bacteria within 3 h. Moderate activity was observed against dermatophyte fungi ( Trichophyton rubrum check for this species in other resources and Microsporum canis check for this species in other resources ). The oils showed no activity against Gram-negative bacteria and yeast. Scannning electron microscopy of S. aureus treated with resin oil from C. martii revealed lysis of the bacteria, causing cellular agglomerates. Transmission electron microscopy revealed disruption and damage to the cell wall, resulting in the release of cytoplasmic compounds, alterations in morphology, and a decrease in cell volume, indicating that copaiba oil may affect the cell wall.

Keywords
copaiba oil - yeast - dermatophyte - bacteria - Copaifera - leguminoseae

 
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