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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 4, 2008, pp. 363-369
Bioline Code: oc08063
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 4, 2008, pp. 363-369

 en Morphological and functional characterizations of Schwann cells stimulated with Mycobacterium leprae check for this species in other resources
da Silva, Tatiana Pereira; da Silva, Ana Caroline Costa; Baruque, Maria da Graça Araújo; de Oliveira, Rosane Barbosa; Machado, Marcelo Pelajo & Sarno, Euzenir Nunes


Nerve damage, a characteristic of leprosy, is the cause of patient deformities and a consequence of Schwann cells (SC) infection by Mycobacterium leprae check for this species in other resources . Although function/dysfunction of SC in human diseases like leprosy is difficult to study, many in vitro models, including SC lines derived from rat and/or human Schwannomas, have been employed. ST88-14 is one of the cell lineages used by many researchers as a model for M. leprae/SC interaction. However, it is necessary to establish the values and limitations of the generated data on the effects of M. leprae in these SC. After evaluating the cell line phenotype in the present study, it is close to non-myelinating SC, making this lineage an ideal model for M. leprae/SC interaction. It was also observed that both M. leprae and PGL-1, a mycobacterial cell-wall component, induced low levels of apoptosis in ST88-14 by a mechanism independent of Bcl-2 family members.

Schwann cell - Mycobacterium leprae - apoptosis

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