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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 5, 2008, pp. 437-442
Bioline Code: oc08077
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 5, 2008, pp. 437-442

 en Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
Kratz, Jadel Müller; Andrighetti-Fröhner, Carla Regina; Kolling, Deise Juliana; Leal, Paulo César; Cirne-Santos, Cláudio César; Yunes, Rosendo Augusto; Nunes, Ricardo José; Trybala, Edward; Bergström, Tomas; Frugulhetti, Izabel CPP; Barardi, Célia Regina Monte & Simões, Cláudia Maria Oliveira

Abstract

The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited.

Keywords
antiviral - HSV-1 - HIV-1 - gallic acid - pentyl gallate

 
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