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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 5, 2008, pp. 493-496
Bioline Code: oc08087
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 5, 2008, pp. 493-496

 en Polymorphism in the Plasmodium vivax check for this species in other resources msp 3α gene in field samples from Tierralta, Colombia
Cristiano, Fabio Aníbal; Pérez, Manuel Alberto; Nicholls, Rubén Santiago & Guerra, Angela Patricia

Abstract

We evaluated the Plasmodium vivax check for this species in other resources polymorphism by studying the Pvmsp-3 gene's polymorphic region by PCR-RFLP in 55 samples from patients living in Tierralta, Colombia. Three different sizes of the Pvmsp-3 gene were found, type A (1,900 bp), type B (1,500 bp) and type C (1,100 bp); most of the samples were type A (96.4 %). The Pvmsp-3 gene exhibited high polymorphism. Seven restriction patterns were found when using Alu I, and nine were found with Hha I; 12 different alleles were obtained when these patterns were combined. The findings suggest that this gene could be used in Colombia as a molecular epidemiologic marker for genotyping P. vivax.

Keywords
Plasmodium vivax - Colombia - genetic polymorphism

 
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