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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 5, 2008, pp. 514-516
Bioline Code: oc08093
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 5, 2008, pp. 514-516

 en Pre-Columbian Chagas disease in Brazil: Trypanosoma cruzi check for this species in other resources I in the archaeological remains of a human in Peruaçu Valley, Minas Gerais, Brazil
Fernandes, Alexandre; Iñiguez, Alena M; Lima, Valdirene S; de Souza, Sheila MF Mendonça; Ferreira, Luiz Fernando; Vicente, Ana Carolina P & Jansen, Ana M


We evaluated the presence and distribution of Trypanosoma cruzi check for this species in other resources DNA in a mummy presenting with megacolon that was dated as approximately 560 ± 40 years old. The mummy was from the Peruaçu Valley in the state of Minas Gerais, Brazil. All samples were positive for T. cruzi minicircle DNA, demonstrating the presence and broad dissemination of the parasite in this body. From one sample, a mini-exon gene fragment was recovered and characterized by sequencing and was found to belong to the T. cruzi I genotype. This finding suggests that T. cruzi I infected humans during the pre-Columbian times and that, in addition to T. cruzi infection, Chagas disease in Brazil most likely preceded European colonization.

Brazilian mummy - Chagas disease - ancient DNA - Trypanosoma cruzi I - megacolon

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