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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 6, 2008, pp. 561-568
Bioline Code: oc08102
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 6, 2008, pp. 561-568

 en Cytokine profile associated with chronic and acute human schistosomiasis mansoni
de Morais, Clarice Neuenschwander Lins; de Souza, Joelma Rodrigues; Melo, Wlademir Gomes; Aroucha, Marcílio L; Miranda, Paulo; Domingues, Ana Lúcia Coutinho; Abath, Frederico Guilherme Coutinho & Montenegro, Silvia Maria Lucena

Abstract

The production and regulation of interleukin (IL) IL-13, IL-4 and interferon-gamma (IFN-γ) was evaluated in 43 schistosomiasis patients with different clinical forms. Whole-blood cultures cytokine production in response to soluble egg antigen (SEA), soluble worm adult preparation (SWAP), mitogens, neutralizing antibodies or recombinant IL-13 were measured by ELISA. After SWAP stimulation, chronic patients, particularly hepatointestinals, produced higher levels of IL-4 in comparison with acute patients, suggesting the presence of a type 2 cytokine profile in these patients. Following SEA and SWAP stimulation, hepatosplenic (HS) patients showed increased levels of IFN-γ when compared with acute patients, indicating that HS disease in humans is associated with a type 1 cytokine response. The mechanisms of immune regulation are apparently different between the clinical stages of the disease, some of which are antigen-specific.

Keywords
Schistosoma mansoni - cytokines - human schistosomiasis

 
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