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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 6, 2008, pp. 606-610
Bioline Code: oc08110
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 6, 2008, pp. 606-610

 en Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica check for this species in other resources serovar Typhimurium vaccine strains
Massis, LM; Braga, CJM; Sbrogio-Almeida, ME; Lauand, C; Newton, SMC; Klebba, PE & Ferreira, LCS

Abstract

In the present study we investigated the flagellin-specific serum (IgG) and fecal (IgA) antibody responses elicited in BALB/c mice immunized with isogenic mutant derivatives of the attenuated Salmonella enterica check for this species in other resources serovar Typhimurium (S. Typhimurium) SL3261 strain expressing phase 1 (FliCi), phase 2 (FljB), or no endogenous flagellin. The data reported here indicate that mice orally immunized with recombinant S. Typhimurium strains do not mount significant systemic or secreted antibody responses to FliCi, FljB or heterologous B-cell epitopes genetically fused to FliCi. These findings are particularly relevant for those interested in the use of flagellins as molecular carriers of heterologous antigens vectored by attenuated S. Typhimurium strains.

Keywords
fagellin - antibody response - attenuated S. Typhimurium strains

 
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