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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 6, 2008, pp. 615-618 		Bioline Code: oc08112
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 6, 2008, pp. 615-618

 en In vitro anti-microbial activity of the Cuban medicinal plants Simarouba glauca check for this species in other resources DC, Melaleuca leucadendron check for this species in other resources L and Artemisia absinthium check for this species in other resources L
Valdés, Aymé Fernández-Calienes; Martínez, Judith Mendiola; Lizama, Ramón Scull; Vermeersch, Marieke; Cos, Paul & Maes, Louis

Abstract

In the present study, an extensive in vitro antimicrobial profiling was performed for three medicinal plants grown in Cuba, namely Simarouba glauca check for this species in other resources , Melaleuca leucadendron check for this species in other resources and Artemisia absinthium check for this species in other resources . Ethanol extracts were tested for their antiprotozoal potential against Trypanosoma b. brucei, Trypanosoma cruzi check for this species in other resources , Leishmania infantum check for this species in other resources and Plasmodium falciparum check for this species in other resources . Antifungal activities were evaluated against Microsporum canis check for this species in other resources and Candida albicans check for this species in other resources whereas Escherichia coli check for this species in other resources and Staphylococcus aureus check for this species in other resources were used as test organisms for antibacterial activity. Cytotoxicity was assessed against human MRC-5 cells. Only M. leucadendron extract showed selective activity against microorganisms tested. Although S. glauca exhibited strong activity against all protozoa, it must be considered non-specific. The value of integrated evaluation of extracts with particular reference to selectivity is discussed.

Keywords
plants - antimicrobial activity - cytotoxicity - selectivity

 
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