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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 7, 2008, pp. 650-652
Bioline Code: oc08118
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 7, 2008, pp. 650-652

 en Antibacterial and cytotoxic activity of Kenyan medicinal plants
Cyrus, Wagate G; Daniel, Gakuya W; Nanyingi, Mark O; Njonge, Francis K & Mbaria, James M

Abstract

Seven medicinal plant extracts traditionally used in Kenya, mainly for management of infectious conditions, were chosen and screened for their antibacterial activity against Gram-negative ( Pseudomonas aeruginosa check for this species in other resources and Escherichia coli check for this species in other resources ) and Gram-positive ( Bacillus cereus check for this species in other resources and Staphylococcus aureus check for this species in other resources ) bacteria. Antibacterial activity was tested using the broth dilution method. Harrisonia abyssinica check for this species in other resources and Terminalia kilimandscharica check for this species in other resources extracts showed significant activity against Gram+ and Gram- bacteria. The methanolic extracts of T. kilimandscharica bark and H. abyssinica bark and leaves showed minimum inhibitory activity against all tested bacteria, with minimal inhibitory concentrations ranging from 25-150 mg/mL. Ajuga remota check for this species in other resources and Amaranthus hybridus check for this species in other resources , which are lethal to brine shrimp nauplii, showed significantly lower antibacterial activity than those that were relatively non-toxic.

Keywords
antibacterial - cytotoxicity - medicinal plants

 
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