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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 7, 2008, pp. 736-740
Bioline Code: oc08133
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 7, 2008, pp. 736-740

 en Genetic divergence between two sympatric species of the Lutzomyia longipalpis check for this species in other resources complex in the paralytic gene, a locus associated with insecticide resistance and lovesong production
Lins, RMMA; Souza, NA & Peixoto, AA

Abstract

The sandfly Lutzomyia longipalpis check for this species in other resources s.l. is the main vector of American Visceral Leishmaniasis. L. longipalpis s.l. is a species complex but until recently the existence of cryptic sibling species among Brazilian populations was a controversial issue. A fragment of paralytic (para), a voltage dependent sodium channel gene associated with insecticide resistance and courtship song production in Drosophila check for this species in other resources , was isolated and used as a molecular marker to study the divergence between two sympatric siblings of the L. longipalpis complex from Sobral, Brazil. The results revealed para as the first single locus DNA marker presenting fixed differences between the two species in this locality. In addition, two low frequency amino-acid changes in an otherwise very conserved region of the channel were observed, raising the possibility that it might be associated with incipient resistance in this vector. To the best of our knowledge, the present study represents the first population genetics analysis of insecticide resistance genes in this important leishmaniasis vector.

Keywords
Lutzomyia longipalpis - Drosophila - insecticide resistance - para - Leishmaniasis - sandflies - sympatric species

 
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