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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 8, 2008, pp. 773-777
Bioline Code: oc08139
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 8, 2008, pp. 773-777

 en Synthesis of Limonene β-Amino Alcohol Derivatives in Support of New Antileishmanial Therapies
Ferrarini, Stela R.; Graebin, Cedric S.; Limberger, Jones; Canto, Rômulo F.S.; Dias, Daiane O.; da Rosa, Ricardo G.; Madeira, Maria de Fátima & Eifler-Lima, Vera L

Abstract

A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.

Keywords
limonene - β-amino alcohol - synthesis - leishmaniasis - Leishmania braziliensis - neglected diseases

 
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