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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 1, 2009, pp. 67-73
Bioline Code: oc09011
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 1, 2009, pp. 67-73

 en A closer look at multiple-clone Plasmodium vivax check for this species in other resources infections: detection methods, prevalence and consequences
Havryliuk, Tatiana & Ferreira, Marcelo U

Abstract

The naturally occurring clonal diversity among field isolates of the major human malaria parasite Plasmodium vivax check for this species in other resources remained unexplored until the early 1990s, when improved molecular methods allowed the use of blood samples obtained directly from patients, without prior in vitro culture, for genotyping purposes. Here we briefly review the molecular strategies currently used to detect genetically distinct clones in patient-derived P. vivax samples, present evidence that multiple-clone P. vivax infections are commonly detected in areas with different levels of malaria transmission and discuss possible evolutionary and epidemiological consequences of the competition between genetically distinct clones in natural human infections. We suggest that, when two or more genetically distinct clones are present in the same host, intra-host competition for limited resources may select for P. vivax traits that represent major public health challenges, such as increased virulence, increased transmissibility and antimalarial drug resistance.

Keywords
malaria - Plasmodium vivax - microsatellites - multiple-clone infections - within-host competition - virulence

 
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