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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 2, 2009, pp. 175-178
Bioline Code: oc09031
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 2, 2009, pp. 175-178

 en Toxoplasma gondii check for this species in other resources infection induces lipid metabolism alterations in the murine host
Milovanović, Ivan; Vujanić, Marija; Klun, Ivana; Bobić, Branko; Nikolić, Aleksandra; Ivović, Vladimir; Trbovich, Alexander M. & Djurković-Djaković, Olgica


Host lipids have been implicated in the pathogenesis of Toxoplasma gondii check for this species in other resources infection. To determine if Toxoplasma infection influences the lipid status in the normal host, we assessed serum lipids of Swiss-Webster mice during infection with the BGD-1 strain (type-2) at a series of time points. Mice were bled at days zero and 42 post-infection, and subgroups were additionally bled on alternating weeks (model 1), or sacrificed at days zero, 14 and 42 (model 2) for the measurement of total cholesterol (Chl), high density lipoproteins (HDL), low density lipoproteins (LDL) and triglycerides and adiponectin. At day 42, brains were harvested for cyst enumeration. A significant decrease (p = 0.02) in HDL and total Chl was first noted in infected vs. control mice at day 14 and persisted to day 42 (p = 0.013). Conversely, LDL was unaltered until day 42, when it increased (p = 0.043). Serum LDL levels at day 42 correlated only with cyst counts of above 300 (found in 44% mice), while the change in HDL between days zero and 42 correlated with both the overall mean cyst count (p = 0.041) and cyst counts above 300 (p = 0.044). Calculated per cyst, this decrease in HDL in individual animals ranged from 0.1-17 μmol/L, with a mean of 2.43 ± 4.14 μmol/L. Serum adiponectin levels remained similar between infected and control mice throughout the experiment.

toxoplasmosis - murine infection - lipid metabolism - cholesterol - adiponectin

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