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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 2, 2009, pp. 273-280
Bioline Code: oc09044
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 2, 2009, pp. 273-280

 en Host immune response to Toxoplasma gondii check for this species in other resources and Ascaris lumbricoides check for this species in other resources in a highly endemic area: evidence of parasite co-immunomodulation properties influencing the outcome of both infections
Bahia-Oliveira, Lílian M.G.; da Silva, Juliana Azevedo; Peixoto-Rangel, Alba Lucinia; Boechat, Marcela Santana Bastos; Oliveira, Annelise M. Wilken Abreu; Massara, Cristiano L. & Peixe, Ricardo Guerra

Abstract

Toxoplasmosis and ascaridiasis evoke polar Th-1 and Th-2 host immune responses, respectively. A study to investigate the specific cytokine profile production by in vitro cultures of peripheral blood mononuclear cells from individuals living under precarious sanitary conditions in a highly endemic area for the parasites Toxoplasma gondii and Ascaris lumbricoides check for this species in other resources was conducted. High levels of both IFN-γ (Th-1) and IL-13 (Th-2) were observed in groups of co-infected individuals presenting toxoplasmic ocular lesions. Significantly lower IL-10 and TGF-β levels were produced by co-infected individuals in comparison with groups of individuals not infected with A. lumbricoides and either positive or negative for T. gondii living under good sanitary conditions (control groups). The possible influence of co-parasitism on the clinical presentation of ocular toxoplasmosis is discussed.

Keywords
Toxoplasma gondii - Ascaris lumbricoides - uveitis - retinochoroiditis - environmental contamination - cytokines

 
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