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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 104, No. 2, 2009, pp. 312-315
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Bioline Code: oc09050
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 2, 2009, pp. 312-315
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Treating Ocular Toxoplasmosis - Current Evidence
Stanford, M.R. & Gilbert, R.E.
Abstract
The current treatment of ocular toxoplasmosis is controversial. The mainstay of treatment has been pyrimethamine
and sulphonamides with or without systemic corticosteroids, but the actual evidence that antibiotics
have a beneficial effect in recurrent toxoplasmic retinochoroiditis is unsupported by randomised placebo controlled
trials. Thus far there have only been three studies looking at the efficacy of antibiotic treatment, all of which were
methodologically weak and two of which were perfomed more than 30 years ago. All studies reported adverse effects
from treatment. There is an urgent need for further randomised, double blind, placebo controlled studies for lesions
in all parts of the retina and to test the efficacy of adjunctive corticosteroid treatment.
Keywords
ocular toxoplasmosis - treatment - current evidence
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