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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 3, 2009, pp. 441-443
Bioline Code: oc09069
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 3, 2009, pp. 441-443

 en RFLP clusters of Mycobacterium tuberculosis check for this species in other resources strains from the Indian Ocean Region: local and South Asian characteristics
Razanamparany, Voahangy Rasolofo; Ramarokoto, Herimanana H; Vololonirina, Elie J; Rasolonavalona, Tiana; Michault, Alain; Pyndiah, Naidu; Seenundun, Rajbunsing; Sandven, Per & Chanteau, Suzanne

Abstract

This is the first study describing the genetic polymorphism of Mycobacterium tuberculosis check for this species in other resources strains in the Indian Ocean Region. Using IS6110 RFLP analysis, 475 M. tuberculosis isolates from Madagascar, Comoros, Mauritius, Mozambique and La Reunion were compared. Of the 332 IS6110 profiles found, 43 were shared by clusters containing 2-65 strains. Six clusters were common to at least two countries. Of 52 families of strains with similar IS6110 profiles, 10 were common to at least two countries. Interestingly, another characteristic was the frequency (16.8%) of IS6110 single-copy strains. These strains could be distinguished using the DR marker. This preliminary evaluation suggests genetic similarity between the strains of the Indian Ocean Region. However, additional markers would be useful for epidemiological studies and to assess the ancient transmission of strains between countries of this region.

Keywords
Mycobacterium tuberculosis - IS6110 RFLP - Indian Ocean Region

 
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