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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 3, 2009, pp. 492-496
Bioline Code: oc09078
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 3, 2009, pp. 492-496

 en The interaction between Histoplasma capsulatum check for this species in other resources cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis
Gorocica, Patricia; Taylor, Maria Lucia; Alvarado-Vásquez, Noé; Pérez-Torres, Armando; Lascurain, Ricardo & Zenteno, Edgar

Abstract

Histoplasma capsulatum check for this species in other resources is an intracellular fungal pathogen that causes respiratory and systemic disease by proliferating within phagocytic cells. The binding of H. capsulatum to phagocytes may be mediated by the pathogen's cell wall carbohydrates, glucans, which consist of glucose homo and hetero-polymers and whose glycosydic linkage types differ between the yeast and mycelial phases. The α-1,3-glucan is considered relevant for H. capsulatum virulence, whereas the β-1,3-glucan is antigenic and participates in the modulation of the host immune response. H. capsulatum cell wall components with lectin-like activity seem to interact with the host cell surface, while host membrane lectin-like receptors can recognize a particular fungal carbohydrate ligand. This review emphasizes the relevance of the main H. capsulatum and host carbohydrate-driven interactions that allow for binding and internalization of the fungal cell into phagocytes and its subsequent avoidance of intracellular elimination.

Keywords
Histoplasma capsulatum - carbohydrates - glucans - polysaccharides - immunomodulation

 
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