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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 3, 2009, pp. 505-512
Bioline Code: oc09080
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 3, 2009, pp. 505-512

 en Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida check for this species in other resources species
Parra-Ortega, B; Cruz-Torres, H; Villa-Tanaca, L & Hernández-Rodríguez, C

Abstract

Aspartyl proteases are a class of enzymes that include the yeast aspartyl proteases and secreted aspartyl protease (Sap) superfamilies. Several Sap superfamily members have been demonstrated or suggested as virulence factors in opportunistic pathogens of the genus Candida check for this species in other resources . Candida albicans check for this species in other resources , Candida tropicalis check for this species in other resources , Candida dubliniensis check for this species in other resources and Candida parapsilosis check for this species in other resources harbour 10, four, eight and three SAP genes, respectively. In this work, genome mining and phylogenetic analyses revealed the presence of new members of the Sap superfamily in C. tropicalis (8), Candida guilliermondii check for this species in other resources (8), C. parapsilosis(11) and Candida lusitaniae check for this species in other resources (3). A total of 12 Sap families, containing proteins with at least 50% similarity, were discovered in opportunistic, pathogenic Candida spp. In several Sap families, at least two subfamilies or orthologous groups were identified, each defined by > 90% sequence similitude, functional similarity and synteny among its members. No new members of previously described Sap families were found in a Candida spp. clinical strain collection; however, the universality of SAPT gene distribution among C. tropicalis strains was demonstrated. In addition, several features of opportunistic pathogenic Candida species, such as gene duplications and inversions, similitude, synteny, putative transcription factor binding sites and genome traits of SAP gene superfamily were described in a molecular evolutionary context.

Keywords
pathogenic Candida spp. - aspartyl proteases phylogeny - evolution

 
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