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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 3, 2009, pp. 522-525
Bioline Code: oc09082
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 3, 2009, pp. 522-525

 en Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela
Rangel, Héctor Rafael; Garzaro, Domingo José; Torres, Jaime Rafael; Castro, Julio; Suarez, Jose Antonio; Naranjo, Laura; Ossenkopp, John; Martinez, Nahír; Resistance Committee Group; Gutierrez, Cristina & Pujol, Flor Helene

Abstract

An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses.

Keywords
HIV - genotypic resistance - diagnostic - Venezuela

 
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