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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 3, 2009, pp. 526-529
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Bioline Code: oc09083
Full paper language: English
Document type: Short Communication
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 3, 2009, pp. 526-529
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Dengue virus type 3 in Brazil: a phylogenetic perspective
de Araújo, Josélio Maria Galvão; Bello, Gonzalo; Schatzmayr, Hermann Gonçalves; dos Santos, Flávia Barreto & Nogueira, Rita Maria Ribeiro
Abstract
Circulation of a new dengue virus (DENV)-3 genotype was recently described in Brazil and Colombia, but the precise classification of this genotype has been controversial. Here we perform phylogenetic and nucleotide-distance analyses of the envelope gene, which support the subdivision of DENV-3 strains into five distinct genotypes (GI to GV) and confirm the classification of the new South American genotype as GV. The extremely low genetic distances between Brazilian GV strains and the prototype Philippines/L11423 GV strain isolated in 1956 raise important questions regarding the origin of GV in South America.
Keywords
dengue virus type 3 - genotypes - Brazil
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Alternative site location: http://memorias.ioc.fiocruz.br
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