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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. s1, 2009, pp. 301-310
Bioline Code: oc09122
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. s1, 2009, pp. 301-310

 en Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
Coatnoan, Nicolas; Berneman, Armand; Chamond, Nathalie & Minoprio, Paola

Abstract

Chagas disease, which is caused by the intracellular parasite Trypanosoma cruzi check for this species in other resources , is a neglected illness with 12-14 million reported cases in endemic geographic regions of Latin America. While the disease still represents an important public health problem in these affected areas, the available therapy, which was introduced more than four decades ago, is far from ideal due to its substantial toxicity, its limited effects on different parasite stocks, and its poor activity during the chronic phase of the disease. For the past 15 years, our group, in collaboration with research groups focused on medicinal chemistry, has been working on experimental chemotherapies for Chagas disease, investigating the biological activity, toxicity, selectivity and cellular targets of different classes of compounds on T. cruzi. In this report, we present an overview of these in vitro and in vivo studies, focusing on the most promising classes of compounds with the aim of contributing to the current knowledge of the treatment of Chagas disease and aiding in the development of a new arsenal of candidates with anti-T. cruzi efficacy.

Keywords
Trypanosoma cruzi - Chagas disease - experimental chemotherapy - aromatic diamidines - propolis - N,N-dimethyl-propenamines - naphthoquinones

 
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