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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 5, 2009, pp. 703-705
Bioline Code: oc09157
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 5, 2009, pp. 703-705

 en Preparation and antitubercular activity of lipophilic diamines and amino alcohols
Júnior, Celso OR; le Hyaric, Mireille; da Costa, Cristiane F; Corrêa, Taís A; Taveira, Aline F; Araújo, Débora P; Reis, Elaine FC; Lourenço, Maria Cristina S; Vicente, Felipe RC & de Almeida, Mauro V

Abstract

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 μg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis check for this species in other resources , with a MIC of 12.5 μg/mL.

Keywords
tuberculosis - amino alcohols - diamines - lipophilicity

 
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