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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 5, 2009, pp. 715-719
Bioline Code: oc09160
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 5, 2009, pp. 715-719

 en Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi check for this species in other resources
Aguirre, Kezia LH; Alves, José B; Silva, Gerluza AB; Cardoso, Jarbas E; Murta, Silvane MF & Ferreira, Anderson J

Abstract

It has been demonstrated that parotid glands of rats infected with Trypanosoma cruzi check for this species in other resources present severe histological alterations; changes include reduction in density and volume of the acini and duct systems and an increase in connective tissue. We evaluated the association between morphological changes in parotid glands, circulating testosterone levels and epidermal growth factor receptor (EGF-R) expression in experimental Chagas disease in rats. Animals at 18 days of infection (acute phase) showed a significant decrease in body weight, serum testosterone levels and EGF-R expression in the parotid gland compared with a control group. Since decreases in body weight could lead to a reduction in circulating testosterone concentration, we believe that the reduction in EGF-R expression in parotid glands of infected rats is due to alterations in testosterone levels and atrophy of parotid glands is caused by changes in EGF-R expression. Additionally, at 50 days (chronic phase) of infection parotid glands showed a normal histological aspect likely due to the normalization of the body weight. These findings suggest that the testosterone-EGF-R axis is involved in the histological changes.

Keywords
parotid glands - histological alterations - Chagas disease - testosterone - EGF-receptor

 
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