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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 6, 2009, pp. 862-864
Bioline Code: oc09182
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 6, 2009, pp. 862-864

 en Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii check for this species in other resources enteric cycle studies
Moura, Marcos de Assis; Amendoeira, Maria Regina Reis & Barbosa, Helene Santos

Abstract

The primary culture of intestinal epithelial cells from domestic cats is an efficient cellular model to study the enteric cycle of Toxoplasma gondii check for this species in other resources in a definitive host. The parasite-host cell ratio can be pointed out as a decisive factor that determines the intracellular fate of bradyzoites forms. The development of the syncytial-like forms of T. gondii was observed using the 1:20 bradyzoite-host cell ratio, resulting in similar forms described in in vivo systems. This alternative study potentially opens up the field for investigation into the molecular aspects of this interaction. This can contribute to the development of new strategies for intervention of a main route by which toxoplasmosis spreads.

Keywords
Toxoplasma gondii - cat enteric cycle of T. gondii - intestinal epithelial cells - primary culture of enterocytes

 
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