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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 6, 2009, pp. 897-900
Bioline Code: oc09188
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 6, 2009, pp. 897-900

 en Relationship among epidemiological parameters of six childhood infections in a non-immunized Brazilian community
Amaku, Marcos; Azevedo, Raymundo Soares; de Castro, Ruy Morgado; Massad, Eduardo & Coutinho, Francisco Antonio Bezerra

Abstract

Epidemiological parameters, such as age-dependent force of infection and average age at infection (ā) were estimated for rubella, varicella, rotavirus A, respiratory syncytial virus, hepatitis A and parvovirus B19 infections for a non-immunized Brazilian community, using the same sera samples. The for the aforementioned diseases were 8.45 years (yr) [95% CI: (7.23, 9.48) yr], 3.90 yr [95% CI: (3.51, 4.28) yr], 1.03 yr [95% CI: (0.96, 1.09) yr], 1.58 yr [95% CI: (1.39, 1.79) yr], 7.17 yr [95% CI: (6.48, 7.80) yr] and 7.43 yr [95% CI: (5.68, 9.59) yr], respectively. The differences between average ages could be explained by factors such as differences in the effectiveness of the protection conferred to newborns by maternally derived antibodies, competition between virus species and age-dependent host susceptibility. Our seroprevalence data may illustrate a case of the above-mentioned mechanisms working together within the same population.

Keywords
seroprevalence - viral diseases - epidemiology - average age - force of infection - Monte Carlo method

 
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