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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 6, 2009, pp. 905-913
Bioline Code: oc09190
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 6, 2009, pp. 905-913

 en Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study
Martins, CAS; Faria, LMD; Souza, MC; Camello, TCF; Velasco, E; Hirata, R Jr; Thuler, LCS & Mattos-Guaraldi, AL


During a five-year period, 932 clinical isolates from cancer patients treated in a Brazilian reference centre were identified as corynebacteria; 86% of the cultures came from patients who had been clinically and microbiologically classified as infected and 77.1% of these patients had been hospitalised (71.1% from surgical wards). The adult solid tumour was the most common underlying malignant disease (66.7%). The univariate and multivariate analyses showed that hospitalised patients had a six-fold greater risk (OR = 5.5, 95% CI = 1.15-26.30 p = 0.033) related to 30-day mortality. The predominant species were Corynebacterium amycolatum check for this species in other resources (44.7%), Corynebacterium minutissimum check for this species in other resources (18.3%) and Corynebacterium pseudodiphtheriticum check for this species in other resources (8.5%). The upper urinary tracts, surgical wounds, lower respiratory tracts, ulcerated tumours and indwelling venous catheters were the most frequent sources of C. amycolatum strains. Corynebacterium jeikeium check for this species in other resources infection occurred primarily in neutropenic patients who have used venous catheters, while infection caused by C. amycolatum and other species emerged mainly in patients with solid tumours.

Corynebacterium amycolatum - Corynebacterium infection - cancer

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