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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 7, 2009, pp. 980-985
Bioline Code: oc09204
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 7, 2009, pp. 980-985

 en In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi check for this species in other resources
Herrera, Cristina; Vallejos, Gabriel A; Loaiza, Randall; Zeledón, Rodrigo; Urbina, Andrea & Sepúlveda-Boza, Silvia

Abstract

The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2-nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi check for this species in other resources . Cytotoxicity studies were performed using Vero cells. The blood trypomastigotes, amastigotes and epimastigotes showed differential degrees of sensitivity towards the four tested compounds; the highest activity against the epimastigotes and blood tripomastigotes was exhibited by N1, followed by N3, N4 and finally N2. In contrast, whereas the compounds N1, N3 and N4 exerted similar magnitudes of activity against amastigotes, N2 was found to be a much less potent compound. According to our results, the compound N1 had the highest level of activity (IC50: 0.6 μM) against epimastigotes.

Keywords
Trypanosoma cruzi - thienyl-2-nitropropene compounds - Chagas disease - antitrypanosomal activity

 
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