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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 7, 2009, pp. 1009-1011
Bioline Code: oc09209
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 7, 2009, pp. 1009-1011

 en Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax check for this species in other resources isolates
Gama, Bianca Ervatti; de Oliveira, Natália Ketrin Almeida; de Souza, José Maria; Daniel-Ribeiro, Cláudio Tadeu & Ferreira-da-Cruz, Maria de Fátima

Abstract

Plasmodium vivax check for this species in other resources control is now being hampered by drug resistance. Orthologous Plasmodium falciparum check for this species in other resources genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characterise pvmdr1 and pvdhfr genes in parasite isolates from a Brazilian endemic area where no molecular investigation had been previously conducted. The pvmdr1 analysis revealed the existence of single (85.7%) and double (14.3%) mutant haplotypes, while the pvdhfr examination showed the presence of double (57.2%) and triple (42.8%) mutant haplotypes. The implications of these findings are discussed.

Keywords
Plasmodium vivax - malaria - chemoresistance - pvmdr1 - pvdhfr

 
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