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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 7, 2009, pp. 1035-1038
Bioline Code: oc09214
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 7, 2009, pp. 1035-1038

 en Molluscicidal activity of Hammada scoparia check for this species in other resources (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula
Mezghani-Jarraya, R; Hammami, H; Ayadi, A & Damak, M

Abstract

The molluscicidal activity of Hammada scoparia check for this species in other resources leaf extracts and the principal alkaloids isolated from them (carnegine and N-methylisosalsoline) were tested against the mollusc gastropod, Galba truncatula, the intermediate host of Fasciola hepatica in Tunisia. The results indicated that the molluscicidal activity was correlated with the presence of alkaloids. A significant molluscicidal value, according to the World Health Organization, was found with the methanol extract (LC50 = 28.93 ppm). Further fractionation of the methanolic extract led to the isolation of two principal alkaloids: carnegine and N-methylisosalsoline. These alkaloids are isoquinolines that have not previously been characterised for their molluscicidal activity. The N-methylisosalsoline possesses the highest molluscicidal activity (LC50 = 0.47 μM against G. truncatula).

Keywords
molluscicidal activity - Galba truncatula - Fasciola hepatica - Hammada scoparia - major alkaloids - N-methylisosalsoline

 
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