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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 2, 2010, pp. 168-173
Bioline Code: oc10029
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 2, 2010, pp. 168-173

 en Chemistry, cytotoxicity and antileishmanial activity of the essential oil from Piper auritum check for this species in other resources
Monzote, Lianet; García, Marley; Montalvo, Ana Margarita; Scull, Ramón & Miranda, Migdalia

Abstract

Leishmaniasis is one of the most important parasitic infections, but current treatments are unsatisfactory due to their toxicity, cost and resistance. Therefore, the development of new antileishmanial compounds is imperative. Many people who live in endemic areas use plants as an alternative to treat the disease. In this paper, we characterised the essential oil from Piper auritum check for this species in other resources , evaluated its cytotoxicity and determined its antileishmanial activity. The chromatogram obtained by gas chromatography revealed 60 peaks and we found that safrole was the most abundant compound, composing 87% of the oil. The oil was active against the promastigotes of Leishmania major check for this species in other resources , Leishmania mexicana check for this species in other resources , Leishmania braziliensis check for this species in other resources and Leishmania donovani check for this species in other resources with a favourable selectivity index against peritoneal macrophages from BALB/c mice. The Piper-oil inhibited the growing of intracellular amastigotes of L. donovani with an IC50 value of 22.3 ± 1.8 μ/mL. This study demonstrates the usefulness of the essential oils as a promising alternative to treat leishmaniasis.

Keywords
Leishmania, Piper auritum, essential oil

 
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