Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
Vol. 105, No. 3, 2010, pp. 293-298
Bioline Code: oc10049
Full paper language: English
Document type: Research Article
Document available free of charge
Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 3, 2010, pp. 293-298
© Copyright © 2010 - Instituto Oswaldo Cruz - Fiocruz
Laboratorial atopy markers in children with human immunodeficiency virus|
Cruz, Cristina Rodrigues; Carvalho, Vania Oliveira; Santos, Rosaly Vieira; Tahan, Tony Tannous; Rossoni, Andrea Maciel Oliveira & Lima, Hermenio Cavalcante
Changes in immune system functions are one of the most important consequences of human immunodeficiency virus (HIV) infection.
Studies have reported a higher prevalence of disease mediated by immunological hypersensitivity mechanisms in HIV-positive patients.
This study aims to observe how immunological changes in HIV-infected children interfere in atopy determinants.
Fifty-seven HIV-positive children were studied between June 2004-August 2005 to evaluate the possible modifications in atopy diagnosis
from prick test environmental allergen reactivity. Patients were subjected to two evaluations: on both occasions, atopic and non-atopic
groups were correlated with immunological (CD4+ and CD8+ lymphocyte concentrations and serum levels of IgA, IgM, IgG and IgE) and
viral parameters (HIV viral load). The percent atopy was 20.05 in the first and 29.82 in the second evaluation and atopy was
diagnosed in patients without immunosuppression or with moderate immunosuppression. Six patients changed from a negative to a
positive atopy profile. One patient with a decreased CD4+ T lymphocyte concentration failed to demonstrate prick test positivity
between evaluations. Multivariate analysis showed that the variables associated with atopy diagnosis included a personal history
of allergic diseases as well as elevated IgE for age and elevated IgE levels. Atopy development in HIV-infected children seems to
be modulated by genetic and environmental factors as well as immunological condition.
HIV, child, immunoglobulin E, allergy
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