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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 4, 2010, pp. 370-373
Bioline Code: oc10065
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 4, 2010, pp. 370-373

 en Detection of IgG1 and IgG4 subtypes reactive against potato apyrase in schistosomiasis patients
de Faria-Pinto, Priscila; Mendes, Rita Gabriela Pedrosa Ribeiro; de Carvalho-Campos, Cristiane; Maia, Ana Carolina Ribeiro Gomes; Oliveira, Áureo Almeida; Coelho, Paulo Marcos Zech & Vasconcelos, Eveline Gomes

Abstract

In this paper, we showed for the first time that the conserved domains within Schistosoma mansoni check for this species in other resources ATP diphos- phohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80%) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses for each patient cured (n = 14) after treatment (AT) with praziquantel revealed variable IgG1 and IgG4 reactivity against potato apyrase. Different antigenic epitopes shared between the vegetable and parasite proteins could be involved in susceptibility or resistance to S. mansoni AT with praziquantel and these possibilities should be explored.

Keywords
Schistosoma mansoni - ATP diphosphohydrolase - potato apyrase

 
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