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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 4, 2010, pp. 555-562
Bioline Code: oc10096
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 4, 2010, pp. 555-562

 en Spatial distribution of Schistosoma mansoni check for this species in other resources infection before and after chemotherapy with two praziquantel doses in a community of Pernambuco, Brazil
Galvão, Aline F.; Favre, Tereza C.; Guimarães, Ricardo J.P.S.; Pereira, Ana P.B.; Zani, Luciana C.; Felipe, Katariny T.; Domingues, Ana Lúcia C.; Carvalho, Omar S.; Barbosa, Constança S. & Pieri, Otávio S.

Abstract

Praziquantel chemotherapy has been the focus of the Schistosomiasis Control Program in Brazil for the past two decades. Nevertheless, information on the impact of selective chemotherapy against Schistosoma mansoni check for this species in other resources infection under the conditions confronted by the health teams in endemic municipalities remains scarce. This paper compares the spatial pattern of infection before and after treatment with either a 40 mg/kg or 60 mg/kg dose of praziquantel by determining the intensity of spatial cluster among patients at 180 and 360 days after treatment. The spatial-temporal distribution of egg-positive patients was analysed in a Geographic Information System using the kernel smoothing technique. While all patients became egg-negative after 21 days, 17.9% and 30.9% reverted to an egg-positive condition after 180 and 360 days, respectively. Both the prevalence and intensity of infection after treatment were significantly lower in the 60 mg/kg than in the 40 mg/kg treatment group. The higher intensity of the kernel in the 40 mg/kg group compared to the 60 mg/kg group, at both 180 and 360 days, ref lects the higher number of reverted cases in the lower dose group. Auxiliary, preventive measures to control transmission should be integrated with chemotherapy to achieve a more enduring impact.

Keywords
schistosomiasis - praziquantel - geographical information systems - spatial clustering - epidemiology

 
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