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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 5, 2010, pp. 642-648
Bioline Code: oc10108
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 5, 2010, pp. 642-648

 en Control of Mycobacterium fortuitum check for this species in other resources and Mycobacterium intracellulare check for this species in other resources infections with respect to distinct granuloma formations in livers of BALB/c mice
da Silva, Tânia Regina Marques; de Oliveira Almeida Petersen, Antonio Luis; de Araújo Santos, Theo; de Almeida, Taís Fontoura; de Freitas, Luiz Antônio Rodrigues & Veras, Patrícia Sampaio Tavares

Abstract

Mycobacterium fortuitum check for this species in other resources is a rapidly growing nontuberculous Mycobacterium that can cause a range of diseases in humans. Complications from M. fortuitum infection have been associated with numerous surgical procedures. A protective immune response against pathogenic mycobacterial infections is dependent on the granuloma formation. Within the granuloma, the macrophage effector response can inhibit bacterial replication and mediate the intracellular killing of bacteria. The granulomatous responses of BALB/c mice to rapidly and slowly growing mycobacteria were assessed in vivo and the bacterial loads in spleens and livers from M. fortuitum and Mycobacterium intracellulare check for this species in other resources -infected mice, as well as the number and size of granulomas in liver sections, were quantified. Bacterial loads were found to be approximately two times lower in M. fortuitum -infected mice than in M. intracellulare-infected mice and M. fortuitum -infected mice presented fewer granulomas compared to M. intracellulare-infected mice. These granulomas were characterized by the presence of Mac-1+ and CD4+ cells. Additionally, IFN-γmRNA expression was higher in the livers of M. fortuitum -infected mice than in those of M. intracellulare-infected mice. These data clearly show that mice are more capable of controlling an infection with M. fortuitum than M. intracellulare. This capacity is likely related to distinct granuloma formations in mice infected with M. fortuitum but not with M. intracellulare.

Keywords
Mycobacterium fortuitum - Mycobacterium intracellulare - granuloma - liver - control of infection

 
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