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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 6, 2010, pp. 834-837
Bioline Code: oc10141
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 6, 2010, pp. 834-837

 en Differential tissue tropism of Trypanosoma cruzi check for this species in other resources strains: an in vitro study
Andrade, Luciana O; Galvão, Lúcia M.C.; Meirelles, Maria de Nazareth S.L.; Chiari, Egler; Pena, Sergio D.J. & Macedo, Andrea M.

Abstract

We have previously demonstrated selection favoring the JG strain of Trypanosoma cruzi check for this species in other resources in hearts of BALB/c mice that were chronically infected with an equal mixture of the monoclonal JG strain and a clone of the Colombian strain, Col1.7G2. To evaluate whether cell invasion efficiency drives this selection, we infected primary cultures of BALB/c cardiomyocytes using these same T. cruzi populations. Contrary to expectation, Col1.7G2 parasites invaded heart cell cultures in higher numbers than JG parasites; however, intracellular multiplication of JG parasites was more efficient than that of Col1.7G2 parasites. This phenomenon was only observed for cardiomyocytes and not for cultured Vero cells. Double infections (Col1.7G2 + JG) showed similar results. Even though invasion might influence tissue selection, our data strongly suggest that intracellular development is important to determine parasite tissue tropism.

Keywords
Trypanosoma cruzi - Chagas disease - tissue tropism - cardiomyocytes

 
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