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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 7, 2010, pp. 942-944
Bioline Code: oc10162
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 7, 2010, pp. 942-944

 en Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals
Sawanyawisuth, Kittisak; Sawanyawisuth, Kanlayanee; Senthong, Vichai; Limpawattana, Panita; Intapan, Pewpan M.; Tiamkao, Somsak; Jitpimolmard, Suthipun; Chotmongkol, Verajit & Barrett-Connor, Elizabeth

Abstract

The diagnosis of meningitic angiostrongyliasis (MA) is based on clinical criteria. A lumbar puncture is used as a diagnostic tool, but it is an invasive procedure. The blood eosinophil levels are also assessed and used in the diagnosis of this disease. We enrolled 47 patients with serologically proven MA and 131 controls with intestinal parasite infections. An absolute eosinophil count model was found to be the best marker for MA. An eosinophil count of more than 798 cells led to sensitivity, specificity, positive predictive and negative predictive values of 76.6%, 80.2%, 58.1% and 90.5%, respectively. These data support the use of testing for high blood eosinophil levels as a diagnostic tool for MA in individuals that are at risk for this disease.

Keywords
eosinophilia - diagnosis - meningitis - angiostrongyliasis - Angiostrongylus cantonensis

 
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