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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 7, 2010, pp. 945-948
Bioline Code: oc10163
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 7, 2010, pp. 945-948

 en The anticancer drug tamoxifen is active against Trypanosoma cruzi check for this species in other resources in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice
Miguel, Danilo Ciccone; Ferraz, Marcela Lencine; de Oliveira Alves, Rosana; Yokoyama-Yasunaka, Jenicer K.U.; Torrecilhas, Ana Claudia; Romanha, Alvaro José & Uliana, Silvia R.B.

Abstract

The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi check for this species in other resources . In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains. Regardless of the strain used, the drug was active against all life-cycle stages of the parasite with a half maximal effective concentration ranging from 0.7-17.9 μM. Two experimental models of acute Chagas disease were used to evaluate the in vivo efficacy of treatment with tamoxifen. No differences in parasitemia and mortality were observed between control mock-treated and tamoxifen-treated mice.

Keywords
chemotherapy - Chagas disease - selective oestrogen receptor modulator

 
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