Impact of human metapneumovirus infection on in and outpatients for the years 2006-2008 in Southern Brazil|
Debur, Maria C.; Vidal, Luine R. R.; Stroparo, Elenice; Nogueira, Meri B.; Almeida, Sérgio M.; Takahashi, Gislene A.; Rotta, Indianara; Pereira, Luciane A.; Silveira, Clyete S.; Delfraro, Adriana; Nakatani, Sueli M.; Skraba, Irene & Raboni, Sonia M.
The human metapneumovirus (hMPV), member of the Paramyxoviridae family, has been reported as an important
agent involved with acute respiratory infections (ARIs). The aim of this study is to identify hMPV as the etiological
agent of ARIs on in and outpatients in the city of Curitiba, Southern Brazil, and describe clinical data of hMPV sub-
typing. A retrospective study was performed in 1,572 respiratory samples over a period of three years. hMPV was
detected by reverse transcription-polymerase chain reaction and subtyping was performed by nucleotide sequencing.
hMPV was present in 61 (3.9%) samples and subtypes A1, A2a, B1 and B2 were detected. The incidence of hMPV was
higher in outpatients (5.9%), whose mean age was 19.7 years (range 6 months-75 years old), than in inpatients (3%),
whose mean age was 7.6 months (range 1 month-26 years old). The outpatients had upper respiratory tract infections
with flu-like symptoms and all hospitalized children had lower respiratory tract infections. A pediatric patient died
from complications associated with hMPV A2a infection. hMPV has been reported as a respiratory pathogen in all
age groups. No correlation was observed between viral subtype and disease severity in the samples of this study.
human metapneumovirus - subtypes - respiratory infection - inpatients - outpatients