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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 8, 2010, pp. 1010-1018
Bioline Code: oc10173
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 8, 2010, pp. 1010-1018

 en Impact of human metapneumovirus infection on in and outpatients for the years 2006-2008 in Southern Brazil
Debur, Maria C.; Vidal, Luine R. R.; Stroparo, Elenice; Nogueira, Meri B.; Almeida, Sérgio M.; Takahashi, Gislene A.; Rotta, Indianara; Pereira, Luciane A.; Silveira, Clyete S.; Delfraro, Adriana; Nakatani, Sueli M.; Skraba, Irene & Raboni, Sonia M.

Abstract

The human metapneumovirus (hMPV), member of the Paramyxoviridae family, has been reported as an important agent involved with acute respiratory infections (ARIs). The aim of this study is to identify hMPV as the etiological agent of ARIs on in and outpatients in the city of Curitiba, Southern Brazil, and describe clinical data of hMPV sub- typing. A retrospective study was performed in 1,572 respiratory samples over a period of three years. hMPV was detected by reverse transcription-polymerase chain reaction and subtyping was performed by nucleotide sequencing. hMPV was present in 61 (3.9%) samples and subtypes A1, A2a, B1 and B2 were detected. The incidence of hMPV was higher in outpatients (5.9%), whose mean age was 19.7 years (range 6 months-75 years old), than in inpatients (3%), whose mean age was 7.6 months (range 1 month-26 years old). The outpatients had upper respiratory tract infections with flu-like symptoms and all hospitalized children had lower respiratory tract infections. A pediatric patient died from complications associated with hMPV A2a infection. hMPV has been reported as a respiratory pathogen in all age groups. No correlation was observed between viral subtype and disease severity in the samples of this study.

Keywords
human metapneumovirus - subtypes - respiratory infection - inpatients - outpatients

 
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