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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 8, 2010, pp. 1044-1049
Bioline Code: oc10178
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 8, 2010, pp. 1044-1049

 en Molecular epidemiology of HIV-1 clades in Southern Brazil
Raboni, Sonia Mara; de Almeida, Sérgio Monteiro; Rotta, Indianara; Ribeiro, Cléa Elisa Lopes; Rosario, Debra; Vidal, Luine Rosele; Nogueira, Meri Bordignon; Riedel, Maristela; Winhescki, Maria da Graça; Ferreira, Kátia Antunes & Ellis, Ronald

Abstract

Human immunodeficiency virus (HIV) clades B and C account for more than 60% of the HIV-1 infections world- wide. In this paper, we describe the profiles of patients infected with subtypes of HIV-1 from the state of Paraná, Southern Brazil, and correlate them with demographic and epidemiological findings. A retrospective analysis of HIV cases reported from 1999-2007 was also performed. Data from 293 patients were reviewed and 245 were older than 13 (58% female). The distribution of clades was as follows: B 140 (57%), C 67 (23%), F 24 (10%) and mosaic or unique recombinant forms (URFs) 24 (10%). Of the 48 patients younger than 13 years of age (62.5% male), vertical transmission occurred in 46 and the distribution of clades was as follows: B 14 (29%), C 24 (50%), F 7 (15%) and URFs 6 (13%). There was no significant difference in mortality between HIV-1 subtypes. In both groups, patients infected with clade C tended to have higher rates of injection drug use exposure risk.

Keywords
HIV - subtypes - genetic variability - HIV exposure

 
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